The use of statins and aspirin, although not strictly antihypertensive agents, are related to depressed risk of postoperative and hypertension-mediated CVAs.10, 19, 27The use of β antagonists, calcium channel antagonists, and ACE inhibitors/ARI carry disparate results, with some studies displaying benefit and others no benefit (or high risk) in stroke prevention or adverse outcomes.16, 17, 28, 29, 30, 31The diuretics are the mainstay of treatment in heart failure and are used as prophylaxis management regimen for stroke. This evidence concerns the gene ACE and stroke disorder.