The SNPs in folate pathway genes, rs1801133 and rs1801131 of theMTHFRgene, rs1805087 in MS, rs662 of PON1, and ACE gene (not in folate pathway) rs4646994 SNP have dissimilar association with stroke, as per literature.11, 12, 13, 14The most extensively studied SNP in relation to stroke:MTHFRgene rs1801133 SNP is decisively associated with hyperhomocysteinemia, and is an additional risk enhancer for stroke.36None of the studied SNP, except for the rs1801133 ofMTHFR(following regression analysis) was associated with stroke incidence in the current study. The gene discussed is ACE; the disease is Stroke.