MTR and Stroke: The two significant single nucleotide polymorphisms (SNPs) inMTHFRgene, C677T (rs1801133) and A1298C (rs1801131) are also strongly associated with risk of CVA/Stroke, with some studies exhibiting one SNP in favor of the other.11, 12, 13The rs1805087 SNP in methionine synthase (MS) gene although is related to thromboembolic phenomenon still it does not exhibit relation to stroke.13The stroke/CVA is high in patients with rs662 PON1 SNP and rs4646994 ACE SNP.14, 15