B-cell leukemia/lymphoma 3 (BCL3) is a proto-oncogene, acts as a transcriptional co-activator through NF-kappa-B target genes and located on 19q13.2.BCL3gene has also shown a strong association with NS orofacial clefts (NSOCs).47A case-parent trio study showed BCL3 influence risk of CL/P through a parent-of-origin effect with the excess maternal transmission.48Several studies in different populations have implicated the role of BCL3 in development of NSCL/P. This evidence concerns the gene BCL3 and orofacial cleft.