TBX22 and cleft lip: Genome-wide linkage analysis showed the association of TBX22 role in the development of NSCLP.74In addition, mutations in TBX22 were found in individuals with isolated CPO.75, 76, 77It plays a significant role in tooth and upper lip development and causes hypodontia and cleft lip.78DNA methylation study suggests that cleft palate-susceptible gene Tbx22 is associated with gene expression and might be responsible for the developmental failure of palatal fusion, eventually resulting in the formation of cleft palate.79