ABCA4 and orofacial cleft: Further, mutations in theRYKgene were also found to be associated with orofacial clefting.110, 111Significant linkage disequilibrium between Gamma-aminobutyric acid receptor, Beta-3 (GABRB3), and CLP was reported by Scapoli et al and this finding in humans is in agreement with previously reported data obtained with the murine model.112In addition, Baroni et al and Carter et al reported the association of GABRB3 with oral clefts in different populations.113, 114ATP-binding cassette, subfamily A, member 4 (ABCA4) encodes an ATP-binding cassette transporter.