In an animal study, mouse SATB2 is strongly expressed in the developing cleft palate and is similar to the human SATB2 protein.43The identification of SATB2 gene responsible for the craniofacial dysmorphologies associated with deletions and translocations at 2q32-q33, only one region of the genome has been significantly associated with the development of isolated cleft palate.44Glass syndrome characterized by cleft palate, gum hyperplasia, slight micrognathia, generalized osteoporosis, and mental retardation reported from Thai patient,45was caused bySATB2gene mutation. Here, SATB2 is linked to cleft palate.