In an animal study, theDLXgenes caused cleft palate showing the importance of these genes in craniofacial morphogenesis.52Whole-exome sequencing study in a Hispanic mother and son with bilateral CLP confirmed the DLX4 as a potential cause of oral clefts.53, 54, 55Recently, a study showed that none of the distal-less 4 (DLX4) gene SNPs were associated with NSOCs, so it should be interpreted with a caution in the etiology of nonsyndromic orofacial clefts.56 Here, DLX4 is linked to cleft palate.