CLPTM1 and orofacial cleft: Mutation ofCLPTM1genes suggested that a regulatory element in this gene region get affected and which is responsible for the development of orofacial clefts.89, 90However, some studies contradict the role of CLPTM1 in the etiology of NSCL/P as no evidence of an association with oral clefts was found among the SNPs of CLPTM1 selected for testing in Japanese and Irish population.91, 92