ACE and kidney disorder: It has also been established that there are several therapies that can ameliorate the progression of renal disease including ACE inhibitors, blood pressure control, tight diabetes control and perhaps low protein diets; however, in trials examining these therapeutic modalities there remains a very significant risk of progression of renal disease in the subjects receiving optimal therapy (Lewis et al., 1993; Klahr et al., 1994; DCCT, 1995; Brenner et al., 2001; Lewis et al., 2001; Wright et al., 2002; Niki et al., 2015).