Among non-critical COVID-19 patients, the top five up-regulated proteins were haptoglobin (41-fold), C-reactive protein (40-fold), trypsin-3 (14-fold), adenomatous polyposis coli protein (11-fold), and hyaluronan-binding protein 2 (10-fold) while immunoglobulin kappa variables 1–5 (10-fold), immunoglobulin heavy variables 3–64D (7-fold), fibrinogen gamma chain (5-fold), C4b-binding protein alpha chain (5-fold), and C4b-binding protein beta chain (5-fold) were under-expressed. This evidence concerns the gene C4BPB and COVID-19.