Regarding neutrophil count, we found an increase in neutrophil among critical COVID-19 patients, and our analysis of exosomal cargo revealed a positive correlation with FGA protein, which is implicated in neutrophil activation (Rubel et al., 2001) but also with TPI1 protein, which has already been found in exosome cargo (Vargas et al., 2016), and with other inflammatory proteins (i.e., SAA1, coagulation factor XI, etc.). The gene discussed is TPI1; the disease is COVID-19.