Because of this, SIRT1 knockout sepsis mice appear to have active NF-κB, STAT3, and extracellular signal-regulated kinase (ERK) 1/2, thus providing the lungs with an unusually strong inflammatory signal by upregulating a range of pro-inflammatory mediators, including IL-ip, IL-6, and TNF-α (110). This evidence concerns the gene STAT3 and Sepsis.