TGFB1 and pulmonary fibrosis: In addition, Wang et al. (117) reported that resveratrol attenuated bleomycin-induced lung fibrosis in mice by inhibiting the MAPK/AP-1 pathway, possibly because resveratrol reduced the levels of c-Fos and c-Jun, thereby inhibiting the miR-21-induced activation of TGF-β/Smad signaling.