Furthermore, we found reduced levels of nuclear SIRT1, along with increased nucleocytoplasmic shuttling, in peripheral blood mononuclear cells (PBMCs) from BPD infants and preterm infants treated with different concentrations of oxygen, suggesting that hyperoxia or oxidative stress modified the activity and distribution of SIRT1 (12). This evidence concerns the gene SIRT1 and bronchopulmonary dysplasia.