They found that a number of biomarkers of DNA hypermethylation including the known (e.g., SEPT9 and IKZF1) and the novel (e.g. TJP2, EMBP1, APBB1IP, CHST11, and KCNQ5) genes were detected in cfDNA of CRC (Li et al., 2019). This evidence concerns the gene TJP2 and colorectal carcinoma.