Li et al. (2019a) suggested that NCoR1 has a protective cardiac effect by suppressing cardiac hypertrophy and Wang et al. (2018) have shown that NCoR1 is downregulated in old mouse hearts. In this regard, NCoR1 is not the only transcriptional co-repressor involved in aging but also there is SMRT and RIP140 that might play a relevant role (Fan et al., 2013; Liu et al., 2013). Here, NCOR1 is linked to cardiac hypertrophy.