Additionally, GSVA showed oligodendrocyte subcluster 9 was enriched in IL-6, complement, TNF-α pathway, and Kras signaling, suggesting that Sgk3 from oligodendrocytes may play an important role regulating oligodendrocyte viability and inflammatory responses during the acute stage of ischemic stroke (Inoue et al., 2016). This evidence concerns the gene KRAS and ischemic stroke.