Circulating levels of adiponectin are decreased in patients with obesity and T2DM (Hotta et al., 2000; Engeli et al., 2003), suggesting that dysregulation of adiponectin may be relevant to obesity-linked endothelial dysfunction in these individuals (Cho et al., 2002; Katsiki et al., 2017). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.