CCR5 and Insulin resistance: Kitade et al. (2012) showed that a higher gene expression of CCR5 in the white adipose tissue of High Fat Diet (HFD)-induced obese mice was concomitant to an accumulation of macrophages in this tissue. Importantly, mice deficient for CCR5 in their myeloid lineage did not develop insulin resistance and diabetes normally induced by HFD. Loss of CCR5 was associated with a reduction in total adipose tissue macrophage content and polarization of macrophages toward and an anti-inflammatory M2-dominant phenotype in the adipose tissue (Kitade et al., 2012).