However, treatment with Ro 45-2081, a TNFα antagonist (recombinant fusion protein that consists of the soluble TNF-receptor linked to the Fc portion of human IgG1), had no effect on blood glucose levels and insulin-mediated glucose uptake in patients with T2DM (Paquot et al., 2000). The gene discussed is INS; the disease is type 2 diabetes mellitus.