Additionally, altered Cav1 and Cavin1 expression, mutations in human Caveolin genes, as well as modified caveolae endocytosis and trafficking can be linked to metabolic diseases including obesity and lipodystrophy (Catalán et al., 2008; Kim et al., 2008; Pilch and Liu, 2011; Schrauwen et al., 2015; Matthaeus et al., 2020), cancer (Lee et al., 2002; Martinez-Outschoorn et al., 2015; Ketteler and Klein, 2018) as well as cardiovascular diseases (Cohen et al., 2004a; Han et al., 2016a; Lian et al., 2019) or myopathies (Gazzerro et al., 2010; Dewulf et al., 2019). Here, CAV1 is linked to cancer.