Marconi et al. showed that biallelic-null mutations in PTPRJ gene impairs spreading on collagen, fibrinogen, and fibronectin; GPVI-mediated aggregation and secretion; and stromal cell-derived factor (SDF)-driven migration on fibronectin, all of which may contribute to thrombocytopenia (40). The gene discussed is GP6; the disease is Thrombocytopenia.