JAK1 and Behcet disease: It is known that JAK1/STAT3 signaling pathway is activated in some systemic vasculitides (Behcet disease) through the activation of Th1/Th17-type cytokines such as IL-2, interferon (IFN-γ), IL-6, IL-17, and IL-23 but its role in KD is not well-understood (61).