Moreover, some diseases of immune dysregulation fall in differential diagnosis with IPEX syndrome mainly due to the fact that patients can present severe inflammatory bowel disease and other IPEX-like autoimmune features, but they do not show tTreg cell impairment (mutations in ITCH, TPP2, JAK1, PEPD, IL10, and IL10R) (52, 80). This evidence concerns the gene TPP2 and inflammatory bowel disease.