TNF and hereditary elliptocytosis: Recently, a decrease in C-reactive protein (P = 0.01), tumor necrosis factor (TNF) (P = 0.01), FABP-6 (P = 0.009), and claudin-3 (P = 0.002) with a sudden increase in neutrophil oxidation (P = 0.002) was observed in patients with HE following probiotic intervention (Roman et al., 2019); these factors are associated with enhanced immune adaptations that maintain homeostasis in the gut microbiota (Skonieczna-Zydecka et al., 2018).