Methylprednisolone and dexamethasone used at nanomolar concentrations induced cell differentiation and apoptosis in the Kasumi-1 cell line and the U937 cell line engineered to express RUNX1-RUNX1T1 but not in other AML cell lines that do not express the oncoprotein. The gene discussed is RUNX1; the disease is acute myeloid leukemia.