Methylprednisolone and dexamethasone used at nanomolar concentrations induced cell differentiation and apoptosis in the Kasumi-1 cell line and the U937 cell line engineered to express RUNX1-RUNX1T1 but not in other AML cell lines that do not express the oncoprotein. Here, RUNX1T1 is linked to acute myeloid leukemia.