NFKB1 and acute myeloid leukemia: Inflammatory cytokines including IL-1β, IL-6, TNF-α, and growth factors such as insulin-like growth factor (IGF-1), which are responsible for ferritin expression through NF-kB activation, are frequently overexpressed in AML and play a crucial role in the leukemic stem cell niche (13, 29, 40, 41).