RUNX1 mutations are mutually exclusive of recurrent translocations in AML and co-occur with ASXL1 mutations and other gene mutations including epigenetic modifiers (IDH2, KMT2A, EZH2), spliceosome complex (SRSF2, SF3B1) and STAG2, PHF6, and BCOR (107). The gene discussed is SF3B1; the disease is acute myeloid leukemia.