Immunohistochemical analysis of HNSCC specimens and adjacent normal tissues for CCR8 and P2RY14 proteins revealed that CCR8 was significantly over-expressed in HNSCC specimens, whereas P2RY14 was significantly lower expressed than in normal tissues (P<0.05) (Figures 7A, B). The gene discussed is P2RY14; the disease is head and neck squamous cell carcinoma.