The seven genes in our signature were TIMP2, QKI, LCP2, LAMP2, ITGAM, CSF3R, and AAK1. Although these genes are differentially expressed in immune cells or stromal cells, the expression of these genes in normal germinal center B cells and in a subset of DLBCL is uncertain, and our sequencing data comes from tumor tissues, so we cannot distinguish whether the expression level is caused by stromal or tumor components. This evidence concerns the gene ITGAM and neoplasm.