Intracranial hemorrhage was higher in patients receiving BRAF inhibitors plus SRS than in those receiving SRS alone (OR, 3.16 [1.43-6.96], p = 0.004).<h4>Conclusions</h4>BRAF inhibitors in conjunction with SRS as local treatment appear to be efficacious. The gene discussed is BRAF; the disease is intracranial hemorrhage.