Supplementary Table S6 lists those genes with differential expression and at least one differentially methylated region (DMR). Among the genes with both differential expression and differential methylation, pathway analysis identified enrichment in the specific pathways Hypertrophic Cardiomyopathy, MAPK Signaling Pathway, PI3K–Akt Signaling Pathway, and Transcriptional Misregulation in Cancer (Fig. 4E). Here, AKT1 is linked to hypertrophic cardiomyopathy.