Abnormal STRN4 expression can promote cell cycle progression and assist cancer cells in gaining invasive properties by activating downstream transcription factors, including misshapen-like kinase 1, RhoA, TRAF2 and NCK-interacting protein kinase (belonging to germinal center kinases) and platelet-derived growth factor receptor-α (PDGFRA) (13). Here, STRN4 is linked to cancer.