The expression of P4HA1 was significantly associated with the ER status group of breast cancer (OR = 0.38; 95% CI: 0.79–0.80, P = 0.011) but less significantly associated with the PR status group cancer (OR = 1.47; 95% CI: 0.71–3.03, P = 0.29). The gene discussed is P4HA1; the disease is breast cancer.