Also supporting its role as a tumor suppressor, SALL2 upregulated Phorbol 12-Myristate 13 Acetate-Induced Protein-1 (PMAIP-1 also known as Noxa) under genotoxic stress in Jurkat T- acute lymphoblastic leukemia cells and repressed cyclins D1 and E1 during G1/S transition in mouse embryonic fibroblasts (Escobar et al., 2015; Hermosilla et al., 2018). This evidence concerns the gene PMAIP1 and acute lymphoblastic leukemia.