In addition to LN, high serum levels of IL-23 and Th17 cells are closely related to other SLE manifestations, including vasculitis, serositis, lymphopenia, central nervous system and cutaneous involvement and the production of autoantibodies (antinucleosome antibodies, antiphospholipid antibodies, and anti-SS-B/La antibodies) (244, 248–250). The gene discussed is IL37; the disease is systemic lupus erythematosus.