In Supplemental Table S2 it is shown that markers of complement and kallikrein/kinin activation correlate significantly to indices of kidney injury (AKI) and eGFR[creatinine], eGFR[cystatin C], cardiovascular disease (P-N-termpBNP, troponin I, heart rate), pulmonary function (pO2/FiO2), and with the two ICU indices SAPS-3 (probability of death) and SOFA (organ failure). This evidence concerns the gene KLK4 and cardiovascular disorder.