These results suggest that the FoxO, mTOR, and ECM pathways or miRNAs targeting them might be vital targets for the therapy and prevention of Chlamydia-induced fibrosis, which subsequently leads to infertility and could guide the development of therapeutic agents for ameliorating Chlamydia-induced fibrosis in the female upper genital tract. The gene discussed is MTOR; the disease is Infertility.