SMAD7 and neoplasm: Although our study did not identify any direct targets for miR-195a-5p and IGF1R and INSR were only indirectly associated with miR-196a-5p, previous studies have reported the involvement of these miRs with cell proliferation/migration, EMT and tumor suppression by targeting several genes, including Smad7, TRIM14, Cyclin E1, MAP4K3, and IKKα (43, 44).