In animal models, NK cells can induce chemokine (C-C motif) ligand 5 (CCL5) and lymphotactin (XCL1) and recruit cDC1 to the tumor microenvironment; however, tumoral prostaglandin E2 (PGE2) can inhibit this anti-tumoral positive loop (116). The gene discussed is MPPE1; the disease is neoplasm.