PTPN2 and colitis: This may be caused by the enhanced induction of Th1 cells, Th17 cells, and effector and memory CD8+ T cells, but the impaired induction of Tregs after T cell-specific knockout of Tcptp. Myeloid cell-specific loss of TCPTP (TCPTP-LysMCre) also enhanced susceptibility to colitis and serum IL-1β levels in mice (76).