In a murine model of asthma, treatment with soluble schistosome egg antigens (SEA) significantly increased the percentage and suppressive activity of regulatory CD4+CD25+ T cells, inhibited the expression of Th2 cytokines (IL-4 and IL-5), relieved antigen-induced airway inflammation, and suppressed asthma (82). The gene discussed is IL4; the disease is asthma.