In a model of acute GvHD performed by injecting C57BL/6 splenocytes into F1 progeny of C57BL/6 and D2 mice, neutralizing IL-22 antibody was administered simultaneously and results in increased survival as well as suppressed expansion of donor CD8 T cells and decreased disease-associated depletion of host cells, particularly B cells (100). Here, IL22 is linked to graft versus host disease.