With respect to NK cell function, IFN-γ and CD107a expressions were impaired in the Siglec7−CD56dim subsets (Siglec-7−CD57−, Siglec-7−CD57+PD-1−, and Siglec-7−CD57+PD-1+ CD56dim) compared with the Siglec7+CD56dim subset from NAFLD patients (Figures 4G,H), as previously reported (26), and the Siglec-7−CD57+PD-1+ subset were functionally impaired compared with either Siglec7−CD57− or Siglec7−CD57−PD-1− subsets of CD56dim cells (Figures 4G,H). Here, SIGLEC7 is linked to metabolic dysfunction-associated steatotic liver disease.