We identified Hydroxycarboxylic Acid Receptor 3 (HCAR3) and Membrane Metalloendopeptidase (MME) as two of the three downregulated genes similar to the findings of Kangelaris et al. (49) that study changes in gene expression among Acute Respiratory Distress Syndrome (ARDS) patients affected with sepsis. The gene discussed is MME; the disease is acute respiratory distress syndrome.