SPP1 and intrahepatic cholangiocarcinoma: Antibodies to tenascin-C have been used as an ICC stromal marker in at least one animal study (40), and in an effort to identify combinations of antibodies that could be used for prognosis, a combination of high levels of tenascin-C immunoreactivity and low levels of osteopontin immunostaining was found to correlate with low post-surgery survival rates in patients with ICC (41).