SCIN and infection: It is important to consider that at the initial stages of infection in certain tissues, such as the skin epithelium, local opsonins may not be efficient to promote phagocytosis due to the large battery of complement inhibitors that S. aureus produce including staphylococcal complement inhibitor (SCIN), extracellular complement-binding protein (Ecb) and staphylococcal superantigen-like protein (SSL7) (32, 33, 37).