Although our study is not devoid of limitations, the most considerable being the lack of functional studies, the results of the in silico analyses described here will empower the evaluation of other CHEK2, TIAM1, and EWSR1 variants for potential pathogenicity and will reopen the debate regarding the mode of inheritance in FNMTC. Here, CHEK2 is linked to familial papillary or follicular thyroid carcinoma.