The three genes that were studied further with in silico tools interact in this network and play key roles in the aforementioned pathways, thus strengthening the case for a combined effect of all three genes (EWSR1, CHEK2, and TIAM1) as the driving force in the development of FNMTC in this family. Here, TIAM1 is linked to familial papillary or follicular thyroid carcinoma.