Higher levels of circulating VWFAc were found in patients treated with tPA [60.3% (40.4–140.2) vs. 41.1% (25.3–50.2), p < 0.03] and in patients with worse clinical stroke severity by NIHSS score (ANOVA linear trend p < 0.001) with median values of NIHSS 0–7 [20% (15.6–35.3)], NIHSS 7–14 [48% (40.4–53.7)], and NIHSS >14 [57.5% (36.8–126.1)]. Here, PLAT is linked to stroke disorder.