Indeed, several studies have examined the effect of RAAS blockers on plasma ACE2 in patients with heart failure, and consistently shown that the protein concentration and/or activity of the enzyme was either unchanged (Epelman et al., 2008; Uri et al., 2016; Chirinos et al., 2020), or decreased [in one cohort (Sama et al., 2020)], but never increased by these drugs. The gene discussed is ACE2; the disease is heart failure.