AGT and infection: This crucial role of a disrupted ACE2-Ang (1-7)/ ACE-Ang II homeostasis balance has been confirmed by multiple other studies, in many other murine models of lung injury such as those induced by lipopolysaccharide (LPS) administration (Asperen et al., 2010; Wösten-van Asperen et al., 2011; Li et al., 2015; Ye and Liu, 2020), avian influenza A H5N1 (Yan et al., 2015), H7N9 (Yang et al., 2015), or respiratory syncytial virus (Gu et al., 2016) infections, seawater aspiration (Zhang et al., 2018), bleomycine administration (Wang L. et al., 2016), or hyperoxia (Fang et al., 2019).