Interestingly, the ability of RAAS blockers to restore the ACE2-Ang (1-7)/ ACE-Ang II balance was not only demonstrated in models of lung injury but also in different models of cardiovascular disease (for instance in a pig model of cardiac arrest), as reviewed in Supplementary Tables 1A,B (Wang G. et al., 2016). This evidence concerns the gene ACE2 and cardiovascular disorder.