Recently, in human myocardial samples, Stegbauer et al. (2020) showed that ACE2 protein level was increased in patients with severe aortic stenosis (but not in patients with severe mitral valve regurgitation) compared to control patients, and that ACEIs, but not ARBs, were associated with increased ACE2 expression (Stegbauer et al., 2020). The gene discussed is ACE2; the disease is aortic stenosis.