ACE2 and heart failure: Another crucial difference between all experimental models is that although some of them specifically analyzed the impact of RAAS blockade on ACE2 in wild type animals or control conditions (Supplementary Table 1A), others used animal models of pathological conditions such as hypertension, heart failure, or organ injury, in order to analyze their effect in conditions for which they are commonly used in humans (Supplementary Tables 1A,B).