ACE2 and heart failure: Indeed, animal models for diseases such as hypertension (Agata et al., 2006; Takeda et al., 2007; Yang et al., 2013) heart failure (Karram et al., 2005), or lung injury (Asperen et al., 2010; Wösten-van Asperen et al., 2011; Li et al., 2015) were associated with a decreased ACE2 protein expression in most observed tissues compared to wild type or control animals, when other models such as myocardial infarction mostly showed an increased ACE2 expression in the heart (Burrell et al., 2005; Ocaranza et al., 2006; Burchill et al., 2012).