Plasma ACE2 has been shown to be increased in cardiovascular diseases such as heart failure (Epelman et al., 2009; Uri et al., 2016), coronary artery disease (Ortiz-Pérez et al., 2013; Ramchand et al., 2018), aortic stenosis (Ramchand et al., 2020), and atrial fibrillation (Walters et al., 2016). Here, ACE2 is linked to heart failure.