While concerns about the safety of these widely used drugs rapidly spread from the medical literature (Aronson and Ferner, 2020; Diaz, 2020; Esler and Esler, 2020; Fang et al., 2020) to general and social media, other authors suggested that modulating ACE-Ang II versus ACE2-Ang (1-7) homeostasis in favor of the latter, using RAAS blockers, might actually be beneficial in patients with COVID-19 (Hanff et al., 2020; Vaduganathan et al., 2020). This evidence concerns the gene AGT and COVID-19.