ACE2 and aortic stenosis: In a recent study, Ramchand et al. (2020) analyzed plasma and myocardial expression of ACE2 in 22 patients with aortic stenosis and reported that higher circulating ACE2 levels were found in patients with reduced myocardial ACE2 gene expression, suggesting that increased levels of plasma ACE2 might actually reflect downregulation of the enzyme in tissues (Ramchand et al., 2020).