To our knowledge, only two studies reported an increased plasma ACE2 activity associated with RAAS blockers; Soro-Paavonen et al. (2012) showed an increase in plasma ACE2 activity among diabetic patients treated with ACEIs (a similar effect with ARBs was only observed in women), while Anguiano et al., reported that ARBs, but not ACEIs, increased plasma ACE2 activity in some subgroups of patients with chronic kidney disease (including those on dialysis). The gene discussed is ACE2; the disease is chronic kidney disease.