AKT1 and cancer: Among them, the most enriched targets are cancer pathways that involve in pro-inflammatory carcinogenesis, miRNA regulatory mechanisms, PI3K-Akt signaling pathways, p53 signaling pathways, etc. According to the previous research findings (Hung et al., 2007; Tewari et al., 2019), PI3K/Akt pathway can activate PI3K by promoting Akt phosphorylation and regulate cell proliferation, thereby promoting tumor growth.