It was reported that apigenin and luteolin belong to flavonoids, that can inhibit the growth of intestinal adenoma cells by reducing the phosphorylation of AKT and up-regulating the expression of FADD, indicating that apigenin and luteolin can inhibit the invasion and metastasis of tumor cells (Xu et al., 2016; Kang et al., 2019). Here, AKT1 is linked to neoplasm.