The abnormal concentration in the Cerebrospinal Fluid (CSF) of the proteins responsible for the plaque formation, i.e., Aβ42, p-Tau, and total-Tau (t-Tau), is assumed to be a measurable fingerprint of their brain deposition, reflecting neurochemical changes arising from AD pathology (Henry et al., 2013). Here, MAPT is linked to Alzheimer disease.