The presence of extracellular amyloid-beta (Aβ) deposition as neuritic plaques and of intracellular accumulation of hyperphosphorylated tau (p-Tau) as neurofibrillary tangles are the two hallmark lesions that histopathologically characterize the brains of AD patients (Ittner and Götz, 2011). This evidence concerns the gene MAPT and Alzheimer disease.