Next, given the recessive inheritance of NOD2 variants observed in both our pediatric onset and adult IBD cohorts, we estimated the disease risk for the three main known CD risk alleles (p.R702W, p.G908R, and p.L1007fs) in our adult IBD case cohort and their effect sizes using additive, genotypic, and recessive genetic models. The gene discussed is NOD2; the disease is inflammatory bowel disease.