Since 72.4% of our cohort is currently over the age of 50 years, we cannot determine whether the age of onset for IBD occurred prior to the first electronically recorded date of an IBD diagnosis for many recessive NOD2 patients; thus it is possible that other individuals with homozygous or compound heterozygous variants in NOD2 might have had pediatric-onset disease that was not captured in the EHR. This evidence concerns the gene NOD2 and inflammatory bowel disease.