NOD2 and inflammatory bowel disease: In total, 92 of 1,183 (7.8%) of the probands in our pediatric onset IBD cohort conformed to a recessive, Mendelian inheritance mode for NOD2 rare and low frequency (MAF ≤ 5%) deleterious variants (Table 1, Fig. 1, Supplementary Table 1, and Supplementary Table 4).