Our results show an overall reduction in CD45+, CD45high lymphocyte, CD11b+CD45+ myeloid cell, as well as Ly6ChighCD45high and MHCIIlowCD45high inflammatory monocyte/macrophage in brains of Poldip2+/− mice 48 h after cerebral ischemia induction. The gene discussed is PTPRC; the disease is brain ischemia.