EGFR and non-small cell lung carcinoma: For our studies, we used three NSCLC cell lines, A549 (RAS mutant G12S), H1650 (EGFR mutant exon 19 del(E746-A750)), and H1975 (EGFR mutant L858R and T790M), and two patient derived xenografts (PDXs), TM00199 (EGFR mutant L858R), and TM00219 (EGFR mutant del(E746-A750)) and T790M) that represent major genetic drivers of NSCLC45.