Here, we found that the expression of PKD3 and PD-L1 significantly increased after treatment of OSCC cell lines with the PD-1 fusion protein; in parallel, the expression of mesenchymal markers increased, whereas that of epithelial markers decreased, suggesting that the PD-1/PD-L1 pathway can induce EMT in tumour cells. The gene discussed is CD274; the disease is neoplasm.