KRAS and lung adenocarcinoma: These mutations could trigger downstream actin remodeling for macropinocytosis initiation and enhance macropinocytosis in diverse cell lines.113,117,118 As the KRAS mutant lung adenocarcinoma mouse model has an active macropinocytosis due to intensified KRAS signal, Omomyc was predominately located in the lung tumors as Laura Soucek and colleagues recently showed.115 Serum starvation has also been reported as an inducer to augment inherent macropinocytosis and recommended as a preferred procedure in the assay of determining macropinocytic index.119,120