These results are consistent with published data showing that N-cadherin enhances EMT,19 and the EMT and neuroendocrine differentiation share similar properties and typically cooccur in advanced cancers.27–31 Interestingly, as shown in figure 1D, we confirmed that PD-L1 was observed only in N-cadherin-positive tissues (the SCC group). The gene discussed is CDH2; the disease is cancer.