CD274 and Familial prostate cancer: Recently, a new molecular link between EMT-mediated upregulation of PD-L1 expression and CD8+ TIL immunosuppression has been established in human lung cancer.53 EMT directly regulates the expression of PD-L1 and is associated with several other checkpoint ligands53 54; however, our study is the first to show that PD-L1 expression is increased by the EMT marker N-cadherin in prostate cancer.