However, there are some limitations to acknowledge: (1) how N-cadherin regulates FFA production is unknown and requires further research in prostate cancer; (2) if Tregs have reduced proliferation or survival, differential homing, or distinct differentiation, among other possibilities, still requires further research in the future; and (3) the impact of N-cadherin on Treg also been reported in other cancers55 and may need further research in prostate cancer. This evidence concerns the gene CDH2 and prostate cancer.