According to some reports, PD-L1 and IDO-1 are primarily associated with interferongamma (IFN-γ) signaling,32 and online supplemental figure 1A confirms that higher IFN-γ levels were expressed in tumor tissues than in benign tissues and that IFN-γ also accumulated in lymphocytes, where it simulated the TME. Here, CD274 is linked to neoplasm.