STAT3 and intrahepatic cholangiocarcinoma: We found that STAT3 knockdown in ICC cells or pretreatment of ICC cells with S3I-201 alleviated the protumor effects of TANs and TAMs on those cells in vitro (figure 6A–C) and promoted tumor growth and metastasis in mouse xenografts (figure 6D, E, online supplemental figure 7).