ICAM1 and neoplasm: Among GO classifications, biological adhesion involves the adhesion of the symbiont to the host, cell adhesion, intermicrovillar adhesion and multicellular organism adhesion.45 Additionally, radiotherapy leads to upregulation of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in the tumor microenvironment.46 Our results demonstrated that CRT enriched the biological adhesion process and enhanced focal adhesion and cell adhesion molecules in LARC tissues.