These cell lines represent a spectrum of MPM histopathological subtypes and many harbour the genetic aberrations commonly observed in MPM tumours, including inactivation of NF2, CDKN2A and BAP1 genes.31 39 42 58 71 72 However, most studies have not compared cell lines with the original tumour from which they were derived to determine how well they recapitulate the genomic and histopathological features. The gene discussed is NF2; the disease is neoplasm.