TP53 and neoplasm: Only when CKO mice of Nf2;p53; Ink4a/Arf were exposed to asbestos using intrapleural injection, the tumours demonstrated predominantly epithelioid subtype.85 Furthermore, in contrast to the reported rarity of p53 mutations in human epithelioid MPM, CKO mice of Nf2;p53 developed epithelioid MPM.