As both angiopoietin-2 and vWF-A2 can enter the blood plasma through exocytosis of endothelial cell Weibel-Palade bodies (35), we also quantified vWF-A2 and Endothelin-1, which were similarly elevated in patients with severe COVID-19 (Fig. 2F and fig. Here, ANGPT2 is linked to COVID-19.