Based on the observed changes in RANK, CSF1R, TNFR1 and TNFR2 in healthy MOs, a focused analysis of the ChIPseq data showed that there was a significant increase of H3K4me3 in RA CD14+ MOs at the RANK and TNFR1 loci but not TNFR2 and CSF1R (figure 5D, E). Here, TNFRSF11A is linked to rheumatoid arthritis.