However, recent independent studies both in the blood and the synovium have interrogated the molecular signature of both CD14+ MOs and CD1C pre-DC (which are the closest subset to our CD11c+ myeloid precursors) in RA.37 38 Analysis of this publicly available data revealed a high transcriptional correlation between blood and synovial CD1C cells (online supplemental figure S8A), indicating a common cell lineage origin. Here, CD1C is linked to rheumatoid arthritis.