In addition to changes in expression of KIF5 proteins, mutations in the KIF5A gene were associated with several neurodegenerative diseases including hereditary spastic paraplegias (SPG10), Charcot-Marie-Tooth type 2 (CMT2), amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD), and MS, supporting a significant role for KIF5 family members, including KIF5A, in disorders implicating disrupted axonal transport [69–73]. This evidence concerns the gene KIF5A and hereditary spastic paraplegia.