Previous studies in our laboratory have revealed that FGF19 directly activates FGFR4-GSK3β signaling cascade in HCC cells to promote the epithelial-mesenchymal transition (EMT) by upregulating β-catenin pathway and provide a cytoprotective role against endoplasmic reticulum (ER) stress by promoting Nrf2 pathway [6, 7]. Here, GSK3B is linked to hepatocellular carcinoma.